蒋文雯老师个人简介

教师简介

       蒋文雯，女，理学博士，贵州大学副教授，硕士研究生导师，主要从事中药的药效物质基础与药理作用机理研究以及分子药理学、网络药理学研究；其间主持和参与完成多项国家省部级课题任务，发表学术论文30余篇，获得授权的发明专利3项。

       邮箱：jww1001@sina.com

学术兼职：中国药理学会会员

主要贡献

【主持和参与项目】

1. 贵州省科技计划项目，黔科合基础[2019]1120号，基于网络药理学探究常用活血化瘀中药“扰动”TF及相关靶点的研究，主持。

2. 贵州省科技计划项目，黔科合平台人才[2017]5788号，基于网络药理学探究常用活血化瘀中药“扰动”TF及相关靶点的研究，主持。

3. 国家自然科学基金 地区科学基金项目，82060263，Mdm2核定位介导β-arrestin2去泛素化和诱捕Gβγ在D3R脱敏负反馈调控机制的研究，参加。

4. 国家自然科学基金面上项目，81460531，独山瓜馥木“唤醒”休眠型结核杆菌的成分分离、机制探讨和药效评价，参加。

5. 国家自然科学基金面上项目，81172960，冷水花等天然药物抑制细菌粘附的化学成分和作用机制研究，参加。

6. 贵州省科学技术基金项目，黔科合J字[2010] 2200，从贵州民族药中发现α-葡萄糖苷酶抑制剂的研究，主持。

7. 贵州大学引进人才科研项目，贵大人基合字(2010) 039，组织因子天然抑制剂的发现及其作用机理研究，主持。

【近期发表论文】

1. Songqin Yang, Mao Zhao, Yuhan Feng, Xia Zhang, Qiuhong Li, Wenwen Jiang*, Daoping Wang*. Exploring the molecular mechanism of Toddalia asiatica (L.) lam on the treatment of thrombosis based on zebrafish models, network pharmacology and experimental verification. Fitoterapia, 2024,Volume179, 106224.

2. Feng, Yuhan; Ren, Yan; Zhang, Xia; Yang, Songqin; Jiao, Qian; Li, Qiuhong; Jiang, Wenwen*. Metabolites of traditional Chinese medicine targeting PI3K/AKT signaling pathway for hypoglycemic effect in type 2 diabetes. Frontiers in Pharmacology 2024,15:1373711.

3. Yang, S.; Zhao, M.; Lu, M.; Feng, Y.; Zhang, X.; Wang, D.; Jiang, W*. Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway. Curr. Issues Mol. Biol. 2024, 46, 5561–5581.

4. He Shasha, He Xuhua, Pan Sujuan, Jiang wenwen*. Exploring the Mechanism of Chuanxiong Rhizoma against Thrombosis Based on Network Pharmacology, Molecular Docking and Experimental Verification. Molecules. 2023; 28(18):6702.

5. Mao Zhao, Mingxing Lu, Yongjiang Zeng, Shasha He, Yuhan Feng, Songqin Yang, Wenwen Jang*.Taraxasterol Inhibits Hepatic Gluconeogenesis and Increases Glycogen Synthesis via the PI3K/Akt Signaling Pathway. Natural Product Communications. 2023, 18(3): 1–13.

6. He, X. H., Zhao, M., Tian, X. Y., Lu, Y. J., Yang, S. Y., Peng, Q. R., Jiang, W. W*. Redox-responsive nano-micelles containing trisulfide bonds to enhance photodynamic efficacy of zinc naphthalocyanine. Chemical Physics Letters, 2022，803.

7. Xuhua He, Yongjiang Zeng, Wenwen Jiang*. Eleven isoquinoline alkaloids on inhibiting tissue factor activity: structure-activity relationships and molecular docking. Z Naturforsch C J Biosci, 2021, 76 (1-2):11-19.

8. Ren, Yan; Jiang, Wenwen; Luo, Chunli; Zhang, Xiaohan; Huang, Mingjin. Atractylenolide III Ameliorates TNBS-Induced Intestinal Inflammation in Mice by Reducing Oxidative Stress and Regulating Intestinal Flora. Chemistry and Biodiversity, 2021, 18(8). 

9. Ren, Y., Jiang, W. W., Luo, C. L., Zhang, X. H., & Huang, M. J. The Promotive Effect of the Active Ingredients of Atractylodes macrocephala on Intestinal Epithelial Repair Through Activating Ca2+ Pathway. Natural Product Communications, 2021,16(11).

10. Yongjiang Zeng, Xuhua He, Wenwen Jiang*, Junping Kou, and Boyang Yu. Ten Representative Saponins on Tissue Factor Expression in HumanMonocytes:Structure–Activity Relationships and Molecular Docking. Natural Product Communications, 2020,Volume 15(3): 1–10.

11. Wenwen Jiang, JinPing Kou , ShenTao Yuan, Li Sun , BoYang Yu*. A simplified and high-throughput chromogenic assay for testing tissue factor-dependent procoagulant activity. Journal of Biomolecular Screening, 2011, 16(3):295-302.

12.  WenwenJiang, JinPing Kou, Zhi Zhang, BoYangYu*. Effects of twelve representative flavonoids on tissue factor expression in human monocytes: structure-activity relationship. Thrombosis Research. 2009, 124 (6):714-720.

13. 卢明星,赵茂,王道平,曾永江,蒋文雯*. 基于网络药理学-分子对接探讨黄芪生脉散对糖尿病的作用机制.世界科学技术-中医药现代化.2022, 24(09): 3449-3464.

14. 赵光耀,赵坤,蒋文雯*,王道平,张明. 基于网络药理学对蒲公英抑制 α-葡萄糖苷酶活性成分及作用机制的研究.天然产物研究与开发, 2020,32(03):

403-413+440.

15. 陈奕玮,王君,赵坤,赵光耀,蒋文雯*.基于网络药理学探讨三七治疗动脉粥样硬化的作用机制.中医杂志，2019, 60(19): 1684-1691

16. 王君,陈奕玮,赵坤,赵光耀,蒋文雯*.基于网络药理学研究左金丸治疗高血压的分子机制. 中成药, 2019, 41(8): 1976-1981

【专利】

1. 蒋文雯,杨小生,聂昌平,潘艺井,曾浩宏,陶祎. 土大黄、猕猴桃根或田基黄提取物在α- 葡萄糖苷酶抑制剂中的应用. 中国发明专利 ， 专利号：           CN  201510717112.3；授权公告号：CN105213493 B

2. 余伯阳,蒋文雯,寇俊萍,张剑,卢灯翠. 异喹啉类组织因子抑制剂及其医疗用途. 中国发明专利,专利号：CN200810022092.8；授权公告号：CN101327214 B

3. 余伯阳, 寇俊萍, 黄娅琳, 蒋文雯, 刘吉华. 一种防治炎症相关心脑血管疾病的药物靶标及其抑制剂. 中国发明专利，专利号：CN200710024810.0 ；授权公告号：CN 101125146 B

4. 蒋文雯;何莎莎; 何绪华; 陈奕玮 ; 筛选丹参和川芎活性成分为组织因子抑制剂的方法及用途., 2022-10-21, 中国, CN202211297431.X