周康简介
【个人简介】
周康，女，理学博士，副教授，硕士生导师，主要从事天然药物化学和微生物与生化药学的研究，贵州省药学会青委会委员。主持国家自然科学、省科技厅、省教育厅等多项科研课题，以第一作者或通讯作者发表学术论文20余篇。主讲《天然药物化学》、《天然药物化学实验》、《药事管理》、《药学英语》、《有机化合物波谱解析》等专业课程。
研究方向：
1. 酶催化的芳香化合物异戊烯基化
2. 真菌重要次级代谢产物的发掘及其生物合成途径的研究
邮箱：kang_zhou@126.com
【主持项目】
1.国家自然科学基金，基于异戊烯基转移酶催化的淫羊藿素模拟物的高效构建及其抗肿瘤活性研究，2026.01 – 2029. 12。
2. 贵州省科学技术厅，基于DMATS家族的异戊烯基转移酶催化获得淫羊藿素类似物的研究，2025.01–2027.12。
3. 省部共建药用植物功效与利用国家重点实验室开放基金，民族药中双苯吡酮定向异戊烯基化及其抗糖尿病活性研究，2023.11-2025.10，已结题。
4.国家自然科学基金，基于真菌来源异戊烯基转移酶催化的异戊烯基查尔酮的化学酶法合成和其生物活性研究，2021.01–2024.12，已结题。
5.贵州省科学技术厅，异戊烯基查尔酮衍生物的化学酶合成及其抗肿瘤活性研究，2020.03–2023.03，已结题。
6.贵州大学引进人才科研项目，七叶一枝花、菝葜内生真菌的次级代谢产物研究，2019.01–2021.12，已结题。
7.贵州省教育厅青年科技人才成长项目，异戊烯基化生物碱类的化学酶合成及其抗肿瘤、抗菌活性研究，2018.11–2021.10，已结题。
【学术论文】
1. Qi Zhou, Yanzhi Yang, Xia Yu, Chun-Mao Yuan, Kang Zhou (2025) C-Prenylation of dihydrochalcones by prenyltransferases AnaPT and its engineered mutants. Bioorg. Chem. 166, 109131. (二区)
2. Min Yang, Jun Jin,* Jiale Yi, Xia Yu, Chun-Mao Yuan,* and Kang Zhou* (2025) Dimethylallylated stilbenoids by chemo-selective prenyltransferases and their α-glucosidase inhibitory effects. Bioorg. Chem. 157, 108261.(二区)
3. Ying Wu§, Shiyunhua Qian§, Xiang Zhou, Shu-Ming Li, Chun-Mao Yuan, *Song Yang, * and Kang Zhou* (2024) Increasing structure diversity of farnesylated chalcones by a fungal aromatic prenyltransferase. Phytochemistry,224, 114149. (二区)
4. Yanzhi Yang§, Linlan Tao§, Yunyun Li, Ying Wu, Qianqian Ran, Dan Li, Shu-Ming Li, Xia Yu*, Chun-Mao Yuan*, and Kang Zhou* (2024) Fungal prenyltransferase AnaPT and its F265 mutants catalyze the dimethylallylation at the nonaromatic carbon of phloretin. J. Agric. Food Chem. 72 (14), 8018 – 8026. (一区)
5. Qianqian Ran, Linlan Tao, Xiang Zhou, Shu-Ming Li, Chun-Mao Yuan*, Song Yang*, and Kang Zhou* (2023) Geranylation of chalcones by a fungal aromatic prenyltransferase. J. Agric. Food Chem. 71 (11): 4675 – 4682. (一区)
6. Ziwei Song, Yan-Jun Sun, Shuangyu Xu, Gang Li*, Chunmao Yuan*, and Kang Zhou* (2023) Secondary metabolites from the endophytic fungi Fusarium decemcellulare F25 and their antifungal activities. Front. Microbiol. 14: 1127971. (二区)
7. Yunyun Li§, Xiang Zhou§, Shu-Ming Li, Yuping Zhang, Chun-Mao Yuan, Shuzhong He, Zaichang Yang, Song Yang*, and Kang Zhou* (2022) Increasing structural diversity of prenylated chalcones by two fungal prenyltransferases. J. Agric. Food Chem. 70 (5): 1610 – 1617. (一区)
8. Kang Zhou, Song Yang, and Shu-Ming Li* (2021) Naturally occurring prenylated chalcones from plants: Structural diversity, distribution, activities and biosynthesis. Nat. Prod. Rep., 38 (12): 2236 – 2260. (一区)
9. Kang Zhou, Carsten Wunsch, Jungui Dai, and Shu-Ming Li* (2017) Gem-diprenylation of acylphloroglucinols by a fungal prenyltransferase of the dimethylallyltryptophan synthase superfamily. Org. Lett., 19 (2): 388 – 391. (一区)
10. Kang Zhou, Wei Zhao, Xiao-Qing Liu*, and Shu-Ming Li* (2016) Saturation mutagenesis on Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 results in mutants with strongly increased C3-prenylating activity.Appl. Microbiol. Biotechnol., 100 (23): 9943 – 9953. (二区)
11. Kang Zhou, Xia Yu, Xiulan Xie, and Shu-Ming Li* (2015) Complementary flavonoid prenylations by fungal indole prenyltransferases. J. Nat. Prod., 78 (9): 2229 – 2235. (二区)
12. Kang Zhou, Lena Ludwig, and Shu-Ming Li* (2015) Friedel-Crafts alkylation of acylphloroglucinols catalyzed by a fungal indole prenyltransferase. J. Nat. Prod., 78(4): 929 –933. (二区).
【指导本科生竞赛及科研训练项目】
1. 2025年全国大学生生命科学竞赛全国三等奖1项；2024年全国大学生生命科学竞赛全国二等奖1项，贵州省一等奖1项（均为第一指导老师）。
2. 指导大学生“SRT”科研训练项目2项（均为第一指导老师）。
