陈洋老师个人简介

【教师简介】

      陈洋，男，理学博士，贵州大学副教授，硕士研究生导师，主要从事具有重要生理活性天然产物的分子构建、结构多样性改造、药理活性及作用机制研究，以及药物开发应用基础研究。相关研究工作已获多项基金项目支持，近年来以第一作者或通讯作者已发表学术论文30余篇，授权专利2件。

邮箱：ychen1@gzu.edu.cn

【主持项目】

1.   国家自然科学基金面上项目，主持

2.   国家重点研发计划子课题，主持

3.   贵州省自然科学基金面上项目3项，主持

【近三年学术论文】

1. Li, L.; Chen, Y.*.  Modular synthesis of nardosinane sesquiterpenoids: Divergent total syntheses of 4-epi-lemnardosinane a and 8-epi-lemnalemnane A. Org. Chem. Front. 2026, DOI: 10.1039/d6qo00857g.

2. Chen, Y.*; Wu, T.; Yang, H.; Fan, A. Design, synthesis and anti-glioblastoma multiforme activity of N-methoxy-2-(pyrimidin-4-ylamino)benzamide derivatives as focal adhesion kinase inhibitors. Molecular Diversity 2026. DOI: 10.1007/s11030-026-11670-8.

3.  Song, Y.; Chen, Y*. Synthesis, structural and DFT characterization of a bridged spirooxindole scaffold toward (+)-alstonlarsine A. J. Mol. Struct., 2026, 1375, 146886.

4. Xu, Y.; Wu, T.; Chen, K.; Wu, D.; Chen, Y.*; Yan, L.* Design, synthesis, and anti-glioblastoma multiforme evaluation of novel multikinase inhibitors via a cyclization strategy with potent FAK inhibition. Eur. J. Med. Chem. 2026, 312, 118877.

5.  Chen, Y.*; Zuo, M.; Zhao, J.; Xiao, S.; Yang, M.; Liu, L.; He, S.; Huang, J. Synthesis of Chiral 1, 4-Benzodioxane Moiety toward Haedoxans. J. Mol. Struct., 2026, 1352, 144548.

6. Qin, Y.; Chen, Y.*; He, S.*; Yang, L.*  Study on Dearomatization [4＋2] Reactions of Allene Substrates. Chin. J. Org. Chem. 2026, 46, 941-950.

7. Yang, H.; Fan, A.; Song, Y.; Chen, Y.*; Preparation of benzofuran-5-formaldehyde based on formylation conjugated dehydrogenation tandem strategy: a recommended comprehensive teaching experiment for basic organic synthesis. Univ. Chem.,2026,41, 141-148.

8. Chen, Y.*; Zuo, M.; Wu, T.; Huang, J. Diels-Alder reaction towards the synthesis of cephanolide a: Construction of the A/B/C/D ring system, X-ray, DFT, and antibacterial activity. J. Mol. Struct., 2025, 142473.

9. Zuo, M.; Chen, Y.*; Zhao, H.; Wu, T.; He, S.; Huang, J.* Synthesis, X-ray, DFT and antibacterial activity of a novel 1-indanone derivative. J. Mol. Struct., 2025, 1339, 142422.

10. Long, A.; Li, D.; Yan, B.; Yuan, Y.; Liu, H.; Yang, L.; Chen, Y.*; He, S.*, General one-step access to unsymmetric propargylic acetals via alcohol functionalization with allenyl ethers. RSC Adv., 2025,15 (15), 11770-11773.

11. Li, D.; Long, A.; Li, Y.; Zeng, Q.; Yang, L.; Chen, Y.*; He, S.* Concise Synthesis of Ethericins A and B, C10-Deoxygerfelin, and Diorcinol. Synthesis-Stuttgart 2025, 57 (13), 2101-2104.

12. Qu, H.; Yang, E.; Zuo, M.; Li, Z.; Dai, L.; Su, Y.; Zhang, X.; Cheng, Y.; Chen, Y. H.; Chen, Y.* Antifungal effects of metabolites from Arthrinium sp. 2–65 and identification of main active ingredients. BMC Microbiology2025, 25 (1), 594.

13. Qu, H.; Dai, L.; Guo, Z.; Wang, J.; Zhang, X.; Chen, W.; Chen, Y.*, Antifungal activity of dimethyl trisulfide and potential biocontrol against Alternaria alternata on postharvest Lycium barbarum. Eur. J. Plant Pathol., 2025,171 (4), 645-660.

14. Zhang, R.; Fang, Y.; He, S.*; Chen, Y.* Progress in Synthesis of Hetidine-Type C₂₀ Diterpenoid Alkaloids. Chem. & Bio Engineering.  2025, 42 (10), 8–16.

15. Liu, Q.; Zuo, M.; Song, Y.; He, S.; Huang, J.;Chen, Y.*. Bioinspired Total Synthesis and Biological Activity of Pegaharine A. Pest Manag. Sci., 2024,80 (3), 1372-1381.

16. Que, Y.; Lei, W.; Fang, Y.; He, S.; Chen, Y.*, Recent Advances in (4 + 3) Cycloaddition of Allenes. Green Synth. Catal.2024, 5, 270–276.

17. Li, M.; Chen, P.; Liu, H.; Huang, J.*; Chen, Y.*. Review of the Total Synthesis of the Aromatic Abietane Diterpenoid Ferruginol. Synthesis-Stuttgart 2024, 56(09), 1355-1368.

18. Chen, Y.*, Chen, P., Song, Y., Jin, Y. Wu, S. Application of Chemical Transformation Driven Impurity Separation in Experiments Teaching: A Novel Method for Purification of α-Fluorinated Mandelic acid. Univ. Chem.,2024,39, 1-11.

【授权专利】

1. Chen, Y.*; Pan, H.; Zhao, H. Preparation of sex attractant for Phthorimaea operculella. CN115490589A.

2. Chen, Y.*; Ai, L.; Li, M.; Pan, H. Method for preparing 4-chloroindole-3-acetic acid using trifluoroacetic acid. CN114573496A.