周志旭-贵州大学药学院

周志旭

发布时间： 2022-04-27 　浏览次数： 4621

周志旭简介

【教师简介】

周志旭，男，博士，教授，博士/硕士生导师。主要从事小分子靶向抗肿瘤药物的设计、合成及药理活性研究；适合于工业化生产的原料药及中间体合成工艺研究；量子化学理论计算研究。

邮箱：290327618@qq.com

【主要贡献】

主持项目：

1.2026.01 - 2027.12：贵州省留学人才创新创业择优资助项目，主持。

2.2025.01-2028.12：基于SHP2“门闩”型变构位点的新型抑制剂设计、合成及抗肿瘤活性研究，国家自然科学基金项目，主持。

3. 2024.08-2026.08：吲哚及氮杂吲哚类药物中间体制备技术，企业委托，主持。

4. 2022.03 - 2025.03：胍法辛的制备工艺开发，企业委托，主持。

5. 2021.08 - 2023.08：雷美替胺的制备工艺开发，企业委托，主持。

6. 2020.03 - 2023.03：新型SHP2 变构抑制剂的设计、合成及活性研究，贵州省科技计划项目，主持。

7. 2018.12 - 2020.12：吡啶稠杂环类BRAF 抑制剂的设计、合成及活性研究，贵州省科技计划项目（黔科合平台人才），主持。

8. 2018.01 - 2020.12：含脲片段硼酸（酯）类化合物的合成，企业委托，主持。

9. 2017.10 - 2020.10：吡啶并[2,3-d]嘧啶类mTOR 抑制剂的设计、合成与构效关系研究，贵州省科技计划项目，主持。

10. 2017.01 - 2020.01：咪唑并[1,2-a]吡啶类化合物的合成与抗肿瘤活性研究，贵州大学引进人才科研项目，主持。

近期发表论文：

1. Yaqun Zhao, Yifan Geng, Haoxiang Xu, Yang Li, Zhixu Zhou*. Chemical Panorama of Triazolopyridines: Evolution of Synthetic Strategies and Applications. Molecular Diversity, 2026, 10.1007/s11030-025-11432-y.

2. Wanxia Zhang, Xiangxiang Liu, Xiaocui Tai, Guohao Tang, Zhixu Zhou*, Zhaopeng Zheng*. Synthesis, crystal structure, DFT and antitumor evaluation of a novel compound containing pyrimidine, pyridine and sulfonamide. Journal of Molecular Structure, 2026, 1355: 145001.

3. Wanxia Zhang, Xiaocui Tai, Xiangxiang Liu, Xiaoxiao Wang, Yunyun Huang, Chunshen Zhao, Zhixu Zhou*, Zhaopeng Zheng*. Synthesis, Crystal Structure, DFT and Antitumor Activity Studies of 1-Octyl-1H-Indole Derivatives. Arabian Journal of Chemistry, 2026, Accepted.

4. Tingting Yuan, Yuanyuan Hou, Zhonghui Tian, Jiale Xu, Zhixu Zhou*, Zhaopeng Zheng*. Characterization of benzofuran derivatives: Crystal structure, DFT analysis and antitumor activity. Journal of Molecular Structure, 2026, 1351: 144255.

5. Guigui Yan, Xiaoxiao Wang, Yuting Wang, Longxie Wei, Zhuyan Huang, Zhichao Yang, Changzhuan Li, Zhixu Zhou*, Zhaopeng Zheng*. Synthesis, crystal structure, DFT, vibrational properties, Hirshfeld surface and in vitro anti-proliferation studies of a novel sulfonamide-containing pyrazolo[1,5-a]pyridine derivative. Journal of Molecular Structure, 2025, 1346, 143255.

6. Wenting Song, Li Li, Lixue Ma, Zaichang Yang, Zhaopeng Zheng, Zhixu Zhou*. Synthesis, crystal structure, DFT, vibrational properties, Hirshfeld surface and antitumor activity studies of a new compound 2-(2-chloro-6-(m-tolyl)imidazo[1,2-a]pyridin-3-yl)-N,N-diethylacetamide. Journal of Molecular Structure, 2024, 1307: 138052.

7. Wenting Song, Li Li, Tianhui Liao, Dongmei Chen, Yihe Jia, Xin Zhao, Zhaopeng Zheng*, Zhixu Zhou*. Synthesis, crystal structure, DFT study, Hirshfeld surface analysis, molecular docking and antitumor activity of a novel SHP2 inhibitor. Journal of Molecular Structure, 2024, 1301, 137320.

8. Xiangxiang Liu, Tianhui Liao, Ni Yang, Shifeng Ban, Yuan Wang, Zhaopeng Zheng*, Zhixu Zhou*. Synthesis, crystal and molecular structures, DFT calculations, spectroscopic (IR, NMR, UV-Vis), vibrational properties and Hirshfeld surface and antitumor activity of two pyrazole boronic acid pinacol ester compounds. Journal of Molecular Structure, 2024, 1299, 137204.

9. Ting Cheng, Jing Jing, Cheng-Yuan Yang, Dan-Na Nie, Kun-Ming Yang, Shuai Tang, Shou-Xu Fu, Ya-Nan Zhang, Zhi-Xu Zhou*. Synthesis, crystal structure and DFT study of 5-bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine. Journal of Structural Chemistry, 2023, 64: 1369–1379.

10. Ni Yang, Wenfei Song, Xiangxiang Liu, Shifeng Ban, Tianhui Liao, Yuan Wang, Zhixu Zhou*. Synthesis, Characterization, Crystal Structure, and DFT Study of 3,4-Diphenyl -1H-pyrrolo[2,3-b]pyridine. Molecular Crystals and Liquid Crystals, 2023,

11. Jiayan Zhang, Wenjun Ye, Sisi Wang, Lihong Yao, Wenting Song, Xiaosha Qiu, Zhixu Zhou*. Synthesis, crystal and molecular structure, vibrational properties, DFT and Hirshfeld surface analyses of ethyl 1-isobutyl-3,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylate.Journal of Molecular Structure, 2023, 1286: 135644.

12. Shifeng Ban, Xiangxiang Liu, Tianhui Liao, Ni Yang, Yuan Wang, Zhixu Zhou*. Synthesis, crystal structure, DFT study, hirshfeld surface analysis and vibrational analysis of 2-{4-[(tert-butoxy-carbonyl)]piperazine-1-yl}pyridine-3-carboxylic acid. Molecular Crystals and Liquid Crystals, 2023, 764: 1, 31-44..

13. Yuanyuan Hou, Wenjun Ye, Sisi Wang, Feng Wu, Chunshen Zhao, Zhixu Zhou*. Synthesis, crystal Structure and DFT Study of ethyl 6-chloro-3-fluoroimidazo[1,2-b]pyridazine-2-carboxylate. Russian Journal of General Chemistry, 2023, 1283: 135342.

14. Sisi Wang, Wenjun Ye, Wenting Song, Lihong Yao, Jiayan zhang, Xiaosha Qiu, Zhixu Zhou*. Synthesis, crystal structure, DFT, vibrational properties, Hirshfeld surface and antitumor activity studies of tert-butyl (R)-(1-(4-(4-amino-1H-pyrrolo[3,2-c]pyridine-1-carbonyl)phenyl)ethyl)carbamate. Journal of Molecular Structure, 2023, 1283: 135342.

15. Bing Liu, Wenjun Ye, Zhaopeng Zheng*, Zhixu Zhou*. Synthesis, crystal structure and DFT study of ethyl (3aR,7R,7aR)-2,2-dimethyl-7-((methylsulfonyl)oxy)-3a,6,7,7a-tetrahydrobenzo[d][1,3]dioxole-5-carboxylate. Journal of Molecular Structure, 2023, 1282: 135214.

16. Yuanyuan Hou, Qingmei Wu, Yumei Chen, Wenjun Ye, Sisi Wang, Chunshen Zhao, Zhixu Zhou*. Synthesis, crystal Structure and DFT Study of tert-butyl 4-(5-bromopyridin-2-yloxy)piperidine-1-carboxylate. Molecular Crystals and Liquid Crystals, 2023, Accepted.

17. Sisi Wang, Yumei Chen, Dongmei Chen, Wenjun Ye, Lihong Yao, Zhuyan Huang, Zhixu Zhou*. Synthesis, crystal structure and vibrational properties studies of (S)-N-(1-phenylethyl)-6-(4-(trifluoromethoxy)phenyl)imidazo[1,2-a]pyridine-2-carboxamide. Journal of Molecular Structure, 2023, 1272:134175.

18. Bing-Qing Li, Jie Ding, Chang-Guang Zeng, Yu-Yang Song, Kai Xia, Yi Ai, Jun-Jie Zhu, Hang Zhong*, Zhi-Xu Zhou*. Synthesis, X-ray crystal structure, DFT calculation and anti-tumor research of novel-configurational dihydroartemisinin purine hybrids. Molecular Crystals and Liquid Crystals, 2022, DOI: 10.1080/15421406.2022.2111882.

19. Guangmei Li, Fan Pan, Yunzhu Tan, Chenglong Yang, Lianyi Luo, Biaodan Tang, Zhixu Zhou*. Synthesis, Crystal Structure, and DFT Study of Dimethyl 4,4'-(Ethane-1,2-Diyl)Dibenzoate. Molecular Crystals and Liquid Crystals, 2023, 755(1): 107-123.

20. Xiang-Xiang Liu, Tian-Hui Liao, Wen-Jun Ye, Hong Sun, Yuan Shi, Qian-Guo, Zhi-Xu Zhou*. Synthesis, Crystal Structure, DFT Calculations and Vibrational Properties of 1-(2-bromo-4-(dimethylamino)phenyl)-4-(2-chlorobenzyl)-[1,2,4]triazolo[4,3-a]quinazolin -5(4H)-one. Molecular Crystals and Liquid Crystals, 2023, 754(1): 31-42.

21. Wenjun Ye, Ye Liu, Qian Ren, Tianhui Liao, Yumei Chen, Dongmei Chen, Sisi Wang, Lihong Yao, Yihe Jia, Chunshen Zhao, Zhixu Zhou*. Design, synthesis and biological evaluation of novel triazoloquinazolinone and imidazoquinazolinone derivatives as allosteric inhibitors of SHP2 phosphatase. Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37(1): 1495-1513.

22. Tianhui Liao, Xiangxiang Liu, Yuan Wang, Zhixu Zhou*. Synthesis, Characterization, Crystal Structure and DFT Studies of 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1-(2,2,2-Trifluoroethyl)-1H-Pyrazole. Molecular Crystals and Liquid Crystals, 2022, 745(1): 60-67.

23. Tao Liu, Yi Ai, Jie Ding, Bingqing Li, Changguang Zeng, Xiaohan Zhang, Hang Zhong*, Zhixu Zhou*. Synthesis, crystal structure, DFT and anticancer study of dihydroartermisinin-paracetamol hybrids. Journal of Molecular Structure, 2022, 1250, (2): 131758.

24. Yumei Chen, Zhongyuan Wang, Dongmei Chen, Wenjun Ye, Tianhui Liao, Chunshen Zhao, Weike Liao, Zhixu Zhou*. Synthesis, crystal and molecular structure, DFT, vibrational spectroscopic, hirshfeld surfaces analyses and molecular docking of a novel compound N-(3-((1-(5-bromo-2-(pyrrolidin-1-yl)phenyl)-5-oxo-[1,2,4]triazolo[4,3-a] quinazolin-4(5H)-yl)methyl)phenyl)-2-thiomorpholinoacetamide. Journal of Molecular Structure, 2022, 1250:131796.

25. Qingmei Wu, Wenjun Ye, Qian Guo, Tianhui Liao, Di Yang, Chunshen Zhao, WeikeLiao, Huifang Chai,Zhixu Zhou*. Synthesis, crystal and molecular structure, vibrational spectroscopic, DFT and molecular docking of 4-(2-chlorobenzyl)-1-(4-hydroxy-3-((4-hydroxypiperidin-1-yl)methyl-5-methoxyphenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Journal of Molecular Structure, 2022, 1247, 131367.

26. Tianhui Liao, Wenjun Ye, Dongmei Chen, Yumei Qin, Yumei Chen, Weike Liao, Zhixu Zhou*. Synthesis, Crystal Structure and DFT Study of 4-(2-Chlorobenzyl)-1-(furan-2-yl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Journal of Heterocyclic Chemistry, 2022, 59(1): 137-143.

27. Liyuan Deng, Hong Sun, Weiyin Hu, Wanpeng Liao, Zhixu Zhou*, Hongyan Pan*. Synthesis, crystal structure, and DFT study of a new derivative of pyrido[2,3-d]pyrimidine. Russian Journal of General Chemistry, 2021, 91: 2489 - 2496.

28. Rongshuang Luo, Zhongyuan Wang, Dali Luo, Yumei Qin, Chunshen Zhao, Di Yang, Tian Lu, Zhixu Zhou*, Zhuyan Huang*. Design, synthesis, and biological evaluation of novel triazoloquinazolinone derivatives as SHP2 protein inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36 (1): 2170 - 2182.

29. Zhixu Zhou, Qing-mei Wu, Zhuyan Huang, Dehou Yu, Hongguang Lu*. Synthesis, crystal structure, DFT, molecular docking and antitumor activity of 4-(2-chlorobenzyl)-1-(5-fluoro-2-hydroxy-3-((4-methylpiperidin-1-yl)methyl) phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Research on Chemical Intermediates, 2021, 47: 3609-3627.

30. Dongmei Chen, Yumei Chen, Qingmei Wu, Xiaohan Zhang, Weike Liao, Zhixu Zhou*. Synthesis, crystal structure and vibrational properties of N-(8-(3-(3-(tert-butyl)ureido)phenyl)imidazo[1,2-a]pyridin-6-yl)acetamide. Journal of Molecular Structure, 2021, 1245: 131101.

31. Dongmei Chen, Yumei Chen, Di Yang, Zhaopeng Zheng, Zhixu Zhou*. Synthesis and anti-tumor activity of novel pyridino[2,3-d]pyrimidine urea derivatives. Journal of Heterocyclic Chemistry, 2021, 58: 1628-1636.

32. Zhixu Zhou, Ye Liu, Qian Ren, Dehou Yu, Hongguang Lu*. Synthesis, crystal structure and DFT study of a novel compound N-(4-(2,4-dimorpholinopyrido[2,3-d]pyrimidin-6-yl) phenyl)pyrrolidine-1-carboxamide.Journal of Molecular Structure, 2021, 1235: 130261.

33. Qingmei Wu, Yumei Chen, Dongmei Chen, Zhixu Zhou*. Synthesis, crystal structure and vibrational properties studies of 2-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)benzonitrile and N-(3-bromobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. Journal of Molecular Structure, 2021, 1229: 129782.

34. Minggang Teng^#, Zhixu Zhou^#, Yumei Qin, Yongli Zhao, Chunshen Zhao*, Jianxin Cao*. A water-soluble fluorescence sensor with high specificity for detecting hydrazine in river water detection and A549 cell imaging. Sensors & Actuators: B. Chemical, 2020, 311: 127914.

【授权专利】

1.周志旭. 一种吡啶并[2,3-d]嘧啶类化合物及其制备方法和用途. 专利号：ZL2020111774872.

2.周志旭,叶文君, 赵春深. 一种五元杂环并喹唑啉酮类化合物及其制备方法. 专利号：ZL2021110310254.

【参编教材】

1. 《制药技术人员从业就业指南》（主编），中国医药科技出版社，2024年.

2. 《制药工艺学》（副主编），中国中医药出版社，2023年.

3. 《药物合成反应》（参编），人民卫生出版社，2023年.

4. 《制药技术人员从业实战案例》（副主编），人民卫生出版社，2023年.

5. 《中药制药设备与车间设计》（副主编），中国中医药出版社，2022年.

6. 《药物制剂设备》（副主编），中国医药科技出版社，2021 年.

7. 《制药原理与设备》（参编），上海科学技术出版社，2019 年.

8. 《制药工程设计》（参编），中国中医药出版社，2018年.