鄢龙家简介

【个人简介】

鄢龙家，男，理学博士，副教授，硕士生导师，贵州省药学会第二届药学青年专业委员会委员，主要从事小分子激酶抑制剂的发现与结构优化、杂环化合物的合成方法研究。相关研究工作已获多项基金项目支持，近年来以第一作者或通讯作者在Eur. J. Med. Chem., Bioorg. Chem.和J. Org. Chem.等期刊发表学术论文30余篇。

邮箱：ylj1089@gzu.edu.cn

【主持项目】

1. 贵州大学人才引进项目：新型嘧啶类Src激酶抑制剂的合成和作用机制研究，2020.01-2022.12 (已结题)

2. 贵州大学培育项目：新型嘧啶类靶向非小细胞肺癌的EGFR 和Src 双靶点抗肿瘤药物的合成与构效关系研究，2020.10-2023.10 (已结题)

3. 省部共建药用植物功效与利用国家重点实验室开放课题项目：EGFR 和 Src 双靶点抑制剂的设计合成与抗肿瘤活性研究，2021.01-2022.12 (已结题)

4. 贵州省科技计划项目：含噻吩片段的嘧啶类EGFR/Src双重抑制剂的设计合成与抗肿瘤活性研究，2022.04-2023.08 (已结题)

5. 贵州省科技计划项目：基于前药策略的FAK/DNA双重抑制剂的分子构建与抗脑胶质瘤活性研究，2024.04-2028.03 (在研)

【学术论文】

1. Longjia Yan, Xin Che, Xu Bai, Yazhong Pei*. Syntheses of novel diaryl[d,f][1,3]diazepines via one-pot Suzuki coupling followed by direct ring closure with carboxylic acids. Molecular Diversity, 2012, 16, 489-501.

2. Longjia Yan*, Hui Wang, Yunpeng Chen, Zhiwei Li, Yazhong Pei*. Synthesis and structure-activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents.Molecular Diversity,2018, 22, 323-333.

3. Longjia Yan, Minggao Deng, Anchao Chen, Yongliang Li, Wanzheng Zhang, Zhiyun Du, Changzhi Dong, Bernard Meunier, Huixiong Chen*. Synthesis of N-pyrimidin[1,3,4]oxadiazoles and N-pyrimidin[1,3,4]-thiadiazoles from 1,3,4-oxadiazol-2-amines and 1,3,4-thiadiazol-2-amines via Pd-catalyzed heteroarylamination. Tetrahedron Letters, 2019, 60, 1359-1362.

4. Longjia Yan, Dan Li, Yi Le, Ping Dong, Li Liu*. Phenothiazine-based fluorescent probe for fluoride ions and its applications in rapid detection of endemic disease. Dyes and Pigments, 2022, 201, 110200.

5. Longjia Yan, Qin Wang, Li Liu, Yi Le*. Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 832-843.

6. Yaqing Zuo, Rongrong Li, Yan Zhang, Guochen Bao, Yi Le, Longjia Yan*. Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, 2742-2754.

7. Yan Zhang, Zhiwu Long, Nian Rao, Yi Le, Li Liu, Longjia Yan*. New phenylisoxazole derivatives: Synthesis, Spectroscopic, X-ray, IR, DFT calculation and biological activity studies. Journal of Molecular Structure, 2023, 1285, 135557.

8. Zhiwu Long, Yaqing Zuo, Rongrong Li, Yi Le, Yawen Dong, Longjia Yan*. Design, synthesis and biological evaluation of 4-arylamino-pyrimidine derivatives as focal adhesion kinase inhibitors. Bioorganic Chemistry, 2023, 140, 106792.

9. Yaqing Zuo, Zhiwu Long, Rongrong Li, Yi Le, Silong Zhang, Huan He, Longjia Yan*. Design, synthesis and antitumor activity of 4-arylamine substituted pyrimidine derivatives as noncovalent EGFR inhibitors overcoming C797S mutation. European Journal of Medicinal Chemistry, 2024, 265, 116106.

10. Yan Zhang, Qingtao Wang, Zhiwu Long, Yaqing Zuo, Li Liu, Longjia Yan*. Synthesis of quinolinoneylnitrones and coumarinylnitrones via a cascade hydroamination and aza-MBH-type reaction. The Journal of Organic Chemistry, 2024, 89, 10327-10332.

11. Yi Wei, Xiaoling He, Zhiwu Long, Yi Le, Li Liu, Longjia Yan*. Discovery of noncovalent diaminopyrimidine-based inhibitors for glioblastoma via a dual FAK/DNA targeting strategy. European Journal of Medicinal Chemistry, 2025, 286, 117288.

【授权专利】

1. 鄢龙家，龙志武，左娅情，乐意，刘力. 一种含噻吩的嘧啶类化合物其制备方法和应用. 授权中国专利号: ZL202210019728.3

2. 鄢龙家，左娅情，龙志武，乐意，刘力. 一种含异羟肟酸片段的嘧啶类化合物其制备方法和应用. 授权中国专利号: ZL202310144039.X