张晓涵简介
【个人简介】
张晓涵，女，理学博士，教授，硕士生导师，博士，主要从事细胞信号转导与重大疾病（神经退行性疾病、肿瘤、代谢性疾病等）相关性及机制研究。相关研究工作已获多项基金项目支持，近年来以第一作者或通讯作者已发表SCI论文20余篇。
邮箱：xhzhang6@gzu.edu.cn
【主持项目】
1. 国家自然科学基金，TRAF6-NUCKS1信号轴调控AKT核激活及其在肺腺癌进展中的作用和机制研究，32460168，2025-01至2028-12，在研，主持；
2. 国家自然科学基金，Mdm2核定位介导b-arrestin2去泛素化和诱捕Gbg在D3R脱敏负反馈调控机制的研究，82060263，2021-01至2024-12，结题，主持；
3. 贵州省科技计划重点项目，不同形貌靶向介孔硅基抗肿瘤纳米载药体系的构建及形貌效应研究，黔科合基础-ZK[2025]重点088，2025-01至2028-12，在研，参与；
4. 贵州省科技计划项目, 多巴胺 D2受体通过调控 PDK1 活性介导胰岛素抵抗作用的分子机制研究，黔科合基础[2020]1Y084，结题，主持；
5.贵州大学培育项目，Mdm2核定位介导β-arrestin2去泛素化和诱捕Gbg在D3R脱敏负反馈调控机制研究，贵大培育[2019]66号，在研，主持；
6.贵州省普通高等学校青年科技人才成长项目，去泛素化的b-Arr2调控多巴胺D3受体脱敏作用的分子机制研究，黔教合KY字[2021]085，结题，主持；
【学术论文】
1. Hu, L., H. Liu, H. Ma, X. Zeng, Y. Cao, B. Liu, H. Li, Zhang X*. 2024. TRAF6-mediated ubiquitination of AKT1 in the nucleus occurs in a β-arrestin2-dependent manner upon insulin stimulation. Biochemical Pharmacology 2024, 226:116362. (IF 5.3)
2. Wu C, Hu L, Liu B, Zeng X, Ma H, Cao Y, Li H, Zhang X*. TRAF6-mediated ubiquitination of AKT in the nucleus is a critical event underlying the desensitization of G protein-coupled receptors. Cell Communication And Signaling 2024,22(1):213. (IF 8.2)
3. Zeng X, Wu C, Cao Y, Li H, Zhang X*. Mdm2-mediated ubiquitination of PKC II is responsible for insulin-induced heterologous desensitization of dopamine D3 receptor. Febs Letters 2024, 598(4):400-414. (IF 3.0)
4. Liu H, Ma H, Zeng X, Wu C, Acharya S, Sudan SK, Zhang X*. Comparative study of the molecular mechanisms underlying the G protein and beta-arrestin-dependent pathways that lead to ERKs activation upon stimulation by Dopamine D(2) receptor. Febs Journal 2023, 290(21):5204-5233. (IF 5.5)
5. Liu H, Acharya S, Sudan SK, Hu L, Wu C, Cao Y, Li H, Zhang X*. Ubiquitination of GRK2 Is Required for the beta-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases. International Journal of Molecular Sciences 2023, 24(12),10031. (IF 4.9)
6. Gao, Z, Min X, K.M. Kim, Liu H, Hu L, Wu C, X. Zhang*. The tyrosine phosphorylation of GRK2 is responsible for activated D2R-mediated insulin resistance. Biochemical And Biophysical Research Communications 2022, 628:40-48. (IF 2.5)
7. Zhang, X., Min, X., Wang, S., Sun, N., & Kim, K. M. Mdm2-mediated ubiquitination of β-arrestin2 in the nucleus occurs in a Gβγ-and clathrin-dependent manner. Biochemical Pharmacology 2020, 178, 114049. (IF 5.3)
8. Zhang, X., Zheng, M., & Kim, K. M. GRK2-mediated receptor phosphorylation and Mdm2-mediated β-arrestin2 ubiquitination drive clathrin-mediated endocytosis of G protein-coupled receptors. Biochemical and Biophysical Research Communications 2020, 533(3), 383-390. (IF 5.3)
9. Zhang, X., Min, X., Zhu, A., & Kim, K. M. A novel molecular mechanism involved in the crosstalks between homologous and PKC-mediated heterologous regulatory pathway of dopamine D2 receptor. Biochemical Pharmacology 2020, 174, 113791. (IF 5.3)
10. Min, X., Zhang, X (co-first author), Sun, N., Acharya, S., & Kim, K. M. Mdm2-mediated ubiquitination of PKCβII in the nucleus mediates clathrin-mediated endocytic activity. Biochemical Pharmacology 2019, 170, 113675. (IF 5.3)
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