赵春深简介
教师简介
赵春深，男，博士，教授，硕士研究生导师。主要从事原料药及医药中间体新工艺开发、新药研发等工作。
邮箱：390214939@qq.com
主要贡献
主持项目：
1. 雷美替胺杂质研发技术开发 产学研项目 主持 2025.01-2027.01
2. 盐酸胍法辛杂质研发技术开发 产学研项目 主持 2023.01-2025.01
3. 系列医药中间体的开发 产学研项目 主持2018.01-2021.01
4. 吡啶类合成砌块的研发 贵州省科技厅 主持2013-05 至2015-06
5. 蛋白酪氨酸激酶抑制剂的合成研究，产学研项目 2012-09-01至 2017-09-31
6. 阿比朵尔衍生物的合成研究，产学研项目 主持 2012-09-01至 2017-09-31
7. 抗骨质疏松药物米诺膦酸的合成研究 贵阳市科技局 主持2012-06至2014-06
近期发表论文：
[1] Yun-Hong Mao, Xiang-Xiang Liu, Hong-Yu Dai, Zhi-Xu Zhou, Chun-Shen Zhao*. Synthesis, crystal structure, density functional theory, and vibration analysis of 4-nitro-N-[(4-nitrophenyl) methyl]-N-phenylbenzenemethanamine. Molecular Crystals and Liquid Crystals, 2024, 768(16): 892-905.
[2] Xiaosha Qiu, Chunshen Zhao*, Lihong Yao, Wenjun Ye, Sisi Wang, Jiayan Zhang, Zhixu Zhou. Synthesis, Crystal Structure and DFT Study of 2-(3-Bromophenyl)-1-(4-morpholinyl)ethenone. Molecular Crystals and Liquid Crystals, 2024, 768(5): 18-31.
[3] Bai-Hui Yang, Li-Xue Ma, Jin-Lan Li, Yan Yang, Zhi-Xu Zhou, Chun-Shen Zhao*. Synthesis, Crystal Structure and DFT Study of 1,1-dimethylethyl (2R)-2- (hydroxydiphenylmethyl)-1-pyrrolidinecarboxylate. Molecular Crystals and Liquid Crystals, 2023, 766(1): 19-29.
[4] Yuan Wang, Hong Sun, Xiangxiang Liu, Tianhui Liao, Ni Yang, Shifeng Ban, Zhixu Zhou, Chunshen Zhao*. Synthesis, crystal structure, DFT, vibrational properties, Hirshfeld surface and antitumor activity studies of 3-((4-methylpiperazin-1-yl)methyl) -1-octyl-5-(p-tolyl)-1H-pyrrolo[2,3-c]pyridine. Journal of Molecular Structure. 2023, 1288: 135760.
[5] Lihong Yao, Wenjun Ye, Sisi Wang, Zhixu Zhou, Xiaosha Qiu, Jiayan Zhang and Chunshen Zhao*. Synthesis, Crystal Structure and DFT Study of tert-butyl 6-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate. Molecular Crystals and Liquid Crystals, 2023, Accepted.
[6] Yuan Wang, Chun-Shen Zhao*. Synthesis, crystal structure and DFT study of ethyl 5-(trimethylsilyl)-1-1H-pyrazole-3-carboxylate. Journal of Structural Chemistry, 2023, Accepted.
[7] Jun-Li Xiao,Rong-Shuang Luo,Yuan Shi, Qian Guo, Zhi-Xu Zhou, Chun-Shen Zhao*. Synthesis, crystal structure and DFT study of a benzenesulfonamide compound 1-ethyl-4-(phenylsulfonyl)piperazine. Molecular Crystals and Liquid Crystals, 2023, Accepted.
[8] Lihong Yao, Qingmei Wu, Yumei Chen, Wenjun Ye, Sisi Wang, Yihe Jia, Zhixu Zhou, Chunshen Zhao*. Synthesis, crystal structure, and DFT study of 1-cyclopropyl-3-(3-((1-(2-methoxyphenyl)-5-oxo-[1, 2, 4]triazolo[4,3-a]quinazolin-4(5H)-yl)methyl)phenylurea. Molecular Crystals and Liquid Crystals, 2023, 754(1): 113-131.
[9] Jun-Li Xiao, Rong-Shuang Luo, Yuan Shi, Qian Guo, Zhi-Xu Zhou, Chun-Shen Zhao*. Synthesis, crystal structure and dft study of benzenesulfonamide compounds 1-ethyl-4-(phenylsulfonyl)piperazine and 1-((3-bromophenyi)sulfonyl)-4- methyipiperazine. Molecular Crystals and Liquid Crystals, 2023, 755(1): 80-90.
[10] Hong Sun, Zhongyuan Wang, Liyuan Deng, Weiyin Hu, Tianhui Liao, Xin Zhao, Zhixu Zhou, Huifang Chai, Chunshen Zhao*. Synthesis, Crystal Structure, and DFT Study of a new Pyrido[2,3-d]pyrimidine Compound 1-(4-((6-Bromopyrido[2,3-d]pyrimidin-4-yl) oxy)phenyl)-3-(2,4-difluorophenyl)urea. Molecular Crystals and Liquid Crystals, 2022, 742(1):10-24.
[11] Zhi-Song Yang, Hui-Fang Chai*, Chun-Shen Zhao*. Synthesis, single crystal x-ray analysis, and DFT calculations of tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate, Molecular Crystals and Liquid Crystals, 2022, 738(1): 67-75.
[12] Liyuan Deng, Tianhui Liao, Hong Sun, Weiyin Hu, Zhixu Zhou, Chunshen Zhao*, Hongyan Pan*. Synthesis, crystal structure and DFT study of a new compound (E)-3-(2-chlorobenzyl)-2-(propan-2-ylidenehydrazineylidene)-2,3-dihydroquinazolin-4(1H)-one, Molecular Crystals and Liquid Crystals, 2022, 737(1): 30-40.
[13] Hong Sun, Liyuan Deng, Weiyin Hu, Tianhui Liao, Weike Liao, Huifang Chai*, Chunshen Zhao*. Synthesis, crystal structure, vibrational properties and DFT studies of 4-(furan-2-ylmethyl)-1-(thiomorpholinomethyl)-[1,2,4]triazolo[4,3-a]quinazon-5(4H)-one. Journal of Molecular Structure. 2022, 1248, 131395.
[14] Weiyin Hu, Liyuan Deng, Hong Sun, Zhixu Zhou, Huifang Chai*, Chunshen Zhao*. Synthesis, crystal structure and DFT study of a new compound 4-(2-chlorobenzyl)-1-(5-fluoro-2-hydroxy-3-(thiomorpholinomethyl)phenyl-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Journal of Heterocyclic Chemistry, 2021, 58: 2102–2108.
[15] Peng-Yue Huang, Zhi-Song Yang, Qing-Mei Wu, De-Zheng Yang, Jun-Jiang Chen, Hui-Fang Chai, Chun-Shen Zhao*. Synthesis, crystal structure and DFT study of compound methyl 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate and (2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(pyrrolidin-1-yl)methanone. Journal of Structural Chemistry, 2021, 62(6): 845-852.
[16] Zhi-Song Yang, Peng-Yue Huang, Jun-Jiang Chen, Yu-Mei Chen, Ting Gao, Hui-Fang Chai, Chun-Shen Zhao*. Synthesis, crystal structure and DFT study of 1-(2-bromobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Journal of Structural Chemistry, 2021, 62(6): 928-937.
[17] Ye Liu, Hao Deng, Qian Ren, Zhixu Zhou, Chunshen Zhao*, Huifang Chai*. Synthesis, characterization of a new compound 4-(2-chlorobenzyl)imidazo[1,2-a]quinazolin-5 (4H)-one and DFT study of crystal structure, MEP and HOMO–LUMO. Journal of Structural Chemistry, 2021, 62(8): 1372-1379.
[18] Qian Ren, Peng-Yue Huang Ye Liu, Wei-Ke Liao, Zhi-Xu Zhou*, Chun-Shen Zhao*. Synthesis, crystal structure and DFT study of a novel compound 4-(2-chlorobenzyl)-1- (5-nitro-2-(pyrrolidin-1-yl)phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Journal of Structural Chemistry, 2021, 62, 1472–1482.
[19] Minggang Teng, Zhixu Zhou, Yumei Qin, Yongli Zhao, Chunshen Zhao*, Jianxin Cao*. A water-soluble fluorescence sensor with high specificity for detecting hydrazine in river water detection and A549 cell imaging. Sensors & Actuators: B. Chemical, 2020, 311: 127914.
[20] Qiuyan Zhang, Zhuyan Huang, Yi Le, Xue Zou, Zhixu Zhou, Chunshen Zhao*. Synthesis, crystal structure and DFT study of 6-hydroxybentazon. Chinese Journal of Structural Chemistry. 2020, 39(2): 269-278.
[21] Ye Liu, Yongli Zhao, Qian Ren, Zhixu Zhou, Huifang Chai, Chunshen Zhao*. Synthesis, crystal structure and DFT study of a novel planar bipyridyl compound 6,6’-bis(trifluoromethyl)-3,3’-bipyridine. Journal of Molecular Structure. 2020, 1208: 127869.
[22] Zhang Dan; Han Jie; Lu Wenchao; Lian Fulin; Wang Jun; Lu Tian; Tao Hongru; Xiao Senhao; Zhang Fengcai; Liu Yu-Chih; Liu Rongfeng; Zhang Naixia; Jiang Hualiang; Chen Kaixian; Zhao Chunshen*; Luo Cheng*. Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening. Bioorganic Chemistry, 2019, 86: 494-500.
[23] Peng Zhao, Zhu-yan Huang, Chunshen Zhao*, Sheng Liu*. Facile Formation of Eight-membered Rings of Indoloazocine Framework via Intramolecular Oxidative Heck Cyclization. Journal of Heterocyclic Chemistry, 2019, 56, 108-113.
[24] Yumei Qin, Dan Long Xiong Zhu, Zhixu Zhou, Huifang Chai*, Chunshen Zhao*. Synthesis, crystal structure and DFT study of a new compound 6-(2-fluorophenyl)-N-(p-tolyl)imidazo[1,2-a]pyridine-2-carboxamide, Journal of Structural Chemistry, 2019, 60(12):1917-1924.
[25] Chunshen Zhao*, Fei Li, Shuo Yang, Li Liu, Zhuyan Huang, Huifang Chai*. Chemoselective iodination of 6-substituted imidazo[1,2-a]pyridine. Chemistry of Heterocyclic Compounds, 2018, 54(5): 568–571.
[26] 肖俊丽，骆荣双，刘钊，周志旭，赵春深. 4-氯-2-甲基吡啶并［3,2-d］嘧啶的合成. 化学研究与应用. 2022, 2(02): 444-448.
[27] 任倩, 刘叶, 朱雄, 周志旭, 赵春深. GSK-A1及其衍生物的合成. 合成化学. 2021, 29(03): 176-183.
[28] 任倩, 刘叶, 高婷, 周志旭, 赵春深, 柴慧芳. 2,2-双（4-氯-2-氟苄基）丙二酸二乙酯的晶体结构和密度泛函理论研究. 人工晶体学报. 2021, 50(02): 338-344.
参编教材：
参编《药物化学》, 宫平主编, 人民卫生出版社, 2014年.
授权专利：
[1] 赵春深,张梦辉,乐意,杨烁. 一种2 羟基 4 甲基苯磺酸的制备方法[P]. ZL201611010090.8
[2] 赵春深,柴慧芳,刘力,黄筑艳,乐意. 一种2-氨基-3-氟吡啶的制备工艺[P]. ZL 201511010908.1
[3] 赵春深,蒋飚,刘力,李焱,柴慧芳,黄筑燕,乐意. 一种2-氨基-4-甲基-5溴吡啶的制备工艺[P]. ZL201410406851.6
[4] 赵春深,蒋飚,张光祥,安丽君,刘天柱,王思东,段炼,滕明刚. 一种6-氯-4-三氟甲基-3-氰基吡啶的制备方法[P]. ZL201310644856.8
[5] 赵春深,蒋飚,刘涛,吴郁林,李飞,肖文斌,赵顺,郭之军. 一种4-氯-5-甲基嘧啶的制备方法[P]. ZL201310376770.1
