钟杭简介
【个人简介】
钟杭，男，理学博士，副教授，硕士生导师，博士，主要从事天然产物结构修饰、小分子化合物设计与合成及生物活性研究。相关研究工作已获多项基金项目支持，近年来以第一作者或通讯作者发表学术论文7篇，授权专利2件。
邮箱：kzhong@gzu.edu.cn
【主持项目】
1. 横向项目：内过氧化合物的合成及开发，2023.08-2026.08，项目经费：72万元；
2. 贵州大学国家自然科学基金培育项目：内过氧型CDK4/6抑制剂的设计、合成及抗乳腺癌活性研究，2021.09-2024.09，项目经费：5.5万元；
3. 贵州省科技厅科学技术基金：下调Cyclin D和抑制 CDK4/6双重活性的青蒿素类小分子设计及抗乳腺癌活性研究，2019.01-2021.12，项目经费：10万元；
4. 贵州省科技厅科学技术基金：青蒿素嘧啶嘌呤拼合物的设计、合成及抗肿瘤活性研究，2017.10-2020.10，项目经费：8万元。
【学术论文】
1. Luolong Qing; Qiying Yu; Changqi Wang; Xing Lu; Yuanli Yang; Xiao Chen; Xiangxiang Li; Jian Min; Weidong Pan; Huan He*; Hang Zhong*; and Silong Zhang*. Discovery of D-ring-contracted artemisinin as a potent hydrophobic tag for targeted protein degradation. Journal of Medicinal Chemistry 2025, 68, 1619-1631.
2. Junjie Zhu; Yi Ai; Junhui Wu; Changguang Zeng; Zhen Cui; Zhengping Zhang; Jiayi Zhu; Changqi Wang; Hang Zhong*. Ring-contracted artemisinin derivatives as novel CDK 4/6 inhibitors: Synthesis and anti-breast cancer evaluation. Chemistry & Biodiversity 2024, 21 (6), No. e202400086
3. Kai Xia; Wei-Jin Qi; Xiao-Qiang Wu; Yu-Yang Song; Jun-Jie Zhu; Yi Ai; Zhen Cui; Zheng-Ping Zhang; Shu-Ai Tang; Yu-Ting Gui; Yue Yuan; Lu Wang; and Hang Zhong*. Synthesis, Structure revision, and anti-inflammatory activity investigation of putative blumeatin. ACS Omega 2023, 8(15):14240-14246.
4. Yu-Yang Song; Kai Xia; Xiao-Qiang Wu; Chang-Guang Zeng; Shu-Ai Tang; Yue Yuan; Yu-Ting Gui; Xiao-Han Zhang; Hang Zhong*. Design, synthesis, and anti-breast cancer activity evaluation of endoperoxide-type pyrido/pyrrolo [2,3-d]pyrimidine derivatives. Journal of Heterocyclic Chemistry 2023, 60(7): 1138-1149.
5. Bingqing Li; Jie Ding; Changguang Zeng; Yuyang Song; Kai Xia; Yi Ai; Junjie Zhu; Hang Zhong*; Zhixu Zhou*. Synthesis, X-ray crystal structure, DFT calculation and anti-tumor research of novel-configurational dihydroartemisinin purine hybrids. Molecular Crystals and Liquid Crystals 2023, 756(1): 58-73.
6. Jie Ding; Bingqing Li; Yi Ai; Changguang Zeng; Xiaohan Zhang; Hang Zhong*. Design, synthesis and anti-breast-cancer evaluation of pyrrolo/pyrido [2,3-d] pyrimidine derivatives. Chemistry of Heterocyclic Compounds 2022, 58(8-9): 438-448.
7. Tao Liu; Yi Ai; Jie Ding; Bingqing Li; Changguang Zeng; Xiaohan Zhang; Hang Zhong*; Zhixu Zhou*. Synthesis, crystal structure, DFT and anticancer study of dihydroartermisinin-paracetamol hybrids. Journal of Molecular Structure 2022, 1250: 131758.
【授权专利】
1. 钟杭；宋雨阳；舒平；唐书嫒；袁玥；归玉婷；内过氧型化合物或其药学上可接受的盐及药物制剂和应用，2024-08-30，中国，CN115850285B
2. 钟杭；丁洁；刘涛；用于治疗和/或预防恶性肿瘤的化合物及药物制剂和应用，2023-07-25，中国，CN114456180B
