周志旭简介

教师简介

周志旭，男，博士，教授，硕士研究生导师。主要从事小分子靶向抗肿瘤药物的设计、合成及药理活性研究；适合于工业化生产的药物及中间体合成工艺研究；量子化学理论计算研究。

邮箱：290327618@qq.com

主要贡献

主持项目：

1. 2025.01-2028.12：基于SHP2“门闩”型变构位点的新型抑制剂设计、合成及抗肿瘤活性研究，国家自然科学基金项目，主持。

2. 2024.08-2026.08：吲哚及氮杂吲哚类药物中间体制备技术，企业委托，主持。

3. 2022.03 - 2025.03：胍法辛的制备工艺开发，企业委托，主持。

4. 2021.08 - 2023.08：雷美替胺的制备工艺开发，企业委托，主持。

5. 2020.03 - 2023.03：新型SHP2 变构抑制剂的设计、合成及活性研究，贵州省科技计划项目，主持。

6. 2018.12 - 2020.12：吡啶稠杂环类BRAF 抑制剂的设计、合成及活性研究，贵州省科技计划项目（黔科合平台人才），主持。

7. 2018.01 - 2020.12：含脲片段硼酸（酯）类化合物的合成，企业委托，主持。

8. 2017.10 - 2020.10：吡啶并[2,3-d]嘧啶类mTOR 抑制剂的设计、合成与构效关系研究，贵州省科技计划项目，主持。

9. 2017.01 - 2020.01：咪唑并[1,2-a]吡啶类化合物的合成与抗肿瘤活性研究，贵州大学引进人才科研项目，主持。

近期发表论文：

1. Wenting Song, Li Li, Lixue Ma, Zaichang Yang, Zhaopeng Zheng, Zhixu Zhou*. Synthesis, crystal structure, DFT, vibrational properties, Hirshfeld surface and antitumor activity studies of a new compound 2-(2-chloro-6-(m-tolyl)imidazo[1,2-a]pyridin-3-yl)-N,N-diethylacetamide. Journal of Molecular Structure, 2024, 1307: 138052.

2. Wenting Song, Li Li, Tianhui Liao, Dongmei Chen, Yihe Jia, Xin Zhao, Zhaopeng Zheng*, Zhixu Zhou*. Synthesis, crystal structure, DFT study, Hirshfeld surface analysis, molecular docking and antitumor activity of a novel SHP2 inhibitor. Journal of Molecular Structure, 2024, 1301, 137320.

3. Xiangxiang Liu, Tianhui Liao, Ni Yang, Shifeng Ban, Yuan Wang, Zhaopeng Zheng*, Zhixu Zhou*. Synthesis, crystal and molecular structures, DFT calculations, spectroscopic (IR, NMR, UV-Vis), vibrational properties and Hirshfeld surface and antitumor activity of two pyrazole boronic acid pinacol ester compounds. Journal of Molecular Structure, 2024, 1299, 137204.

4. Ting Cheng, Jing Jing, Cheng-Yuan Yang, Dan-Na Nie, Kun-Ming Yang, Shuai Tang, Shou-Xu Fu, Ya-Nan Zhang, Zhi-Xu Zhou*. Synthesis, crystal structure and DFT study of 5-bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine. Journal of Structural Chemistry, 2023, 64: 1369–1379.

5. Ni Yang, Wenfei Song, Xiangxiang Liu, Shifeng Ban, Tianhui Liao, Yuan Wang, Zhixu Zhou*. Synthesis, Characterization, Crystal Structure, and DFT Study of 3,4-Diphenyl -1H-pyrrolo[2,3-b]pyridine. Molecular Crystals and Liquid Crystals, 2023,

6. Jiayan Zhang, Wenjun Ye, Sisi Wang, Lihong Yao, Wenting Song, Xiaosha Qiu, Zhixu Zhou*. Synthesis, crystal and molecular structure, vibrational properties, DFT and Hirshfeld surface analyses of ethyl 1-isobutyl-3,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-5-carboxylate.Journal of Molecular Structure, 2023, 1286: 135644.

7. Shifeng Ban, Xiangxiang Liu, Tianhui Liao, Ni Yang, Yuan Wang, Zhixu Zhou*. Synthesis, crystal structure, DFT study, hirshfeld surface analysis and vibrational analysis of 2-{4-[(tert-butoxy-carbonyl)]piperazine-1-yl}pyridine-3-carboxylic acid. Molecular Crystals and Liquid Crystals, 2023, DOI: 10.1080/15421406.2023.2201728.

8. Yuanyuan Hou, Wenjun Ye, Sisi Wang, Feng Wu, Chunshen Zhao, Zhixu Zhou*. Synthesis, crystal Structure and DFT Study of ethyl 6-chloro-3-fluoroimidazo[1,2-b]pyridazine-2-carboxylate. Russian Journal of General Chemistry, 2023, 1283: 135342.

9. Sisi Wang, Wenjun Ye, Wenting Song, Lihong Yao, Jiayan zhang, Xiaosha Qiu, Zhixu Zhou*. Synthesis, crystal structure, DFT, vibrational properties, Hirshfeld surface and antitumor activity studies of tert-butyl (R)-(1-(4-(4-amino-1H-pyrrolo[3,2-c]pyridine-1-carbonyl)phenyl)ethyl)carbamate. Journal of Molecular Structure, 2023, 1283: 135342.

10. Bing Liu, Wenjun Ye, Zhaopeng Zheng*, Zhixu Zhou*. Synthesis, crystal structure and DFT study of ethyl (3aR,7R,7aR)-2,2-dimethyl-7-((methylsulfonyl)oxy)-3a,6,7,7a-tetrahydrobenzo[d][1,3]dioxole-5-carboxylate. Journal of Molecular Structure, 2023, 1282: 135214.

11. Yuanyuan Hou, Qingmei Wu, Yumei Chen, Wenjun Ye, Sisi Wang, Chunshen Zhao, Zhixu Zhou*. Synthesis, crystal Structure and DFT Study of tert-butyl 4-(5-bromopyridin-2-yloxy)piperidine-1-carboxylate. Molecular Crystals and Liquid Crystals, 2023, Accepted.

12. Sisi Wang, Yumei Chen, Dongmei Chen, Wenjun Ye, Lihong Yao, Zhuyan Huang, Zhixu Zhou*. Synthesis, crystal structure and vibrational properties studies of (S)-N-(1-phenylethyl)-6-(4-(trifluoromethoxy)phenyl)imidazo[1,2-a]pyridine-2-carboxamide. Journal of Molecular Structure, 2023, 1272:134175.

13.Bing-Qing Li, Jie Ding, Chang-Guang Zeng, Yu-Yang Song, Kai Xia, Yi Ai, Jun-Jie Zhu, Hang Zhong*, Zhi-Xu Zhou*. Synthesis, X-ray crystal structure, DFT calculation and anti-tumor research of novel-configurational dihydroartemisinin purine hybrids. Molecular Crystals and Liquid Crystals, 2022, DOI: 10.1080/15421406.2022.2111882.

14.Guangmei Li, Fan Pan, Yunzhu Tan, Chenglong Yang, Lianyi Luo, Biaodan Tang, Zhixu Zhou*. Synthesis, Crystal Structure, and DFT Study of Dimethyl 4,4'-(Ethane-1,2-Diyl)Dibenzoate. Molecular Crystals and Liquid Crystals, 2022, DOI: 10.1080/15421406.2022.2110766.

15.Xiang-Xiang Liu, Tian-Hui Liao, Wen-Jun Ye, Hong Sun, Yuan Shi, Qian-Guo, Zhi-Xu Zhou*. Synthesis, Crystal Structure, DFT Calculations and Vibrational Properties of 1-(2-bromo-4-(dimethylamino)phenyl)-4-(2-chlorobenzyl)-[1,2,4] triazolo[4,3-a]quinazolin-5(4H)-one. Molecular Crystals and Liquid Crystals, 2023, 754(1): 31-42.

16.Wenjun Ye, Ye Liu, Qian Ren, Tianhui Liao, Yumei Chen, Dongmei Chen, Sisi Wang, Lihong Yao, Yihe Jia, Chunshen Zhao, Zhixu Zhou*. Design, synthesis and biological evaluation of novel triazoloquinazolinone and imidazoquinazolinone derivatives as allosteric inhibitors of SHP2 phosphatase. Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37(1): 1495-1513.

17.Tianhui Liao, Xiangxiang Liu, Yuan Wang, Zhixu Zhou*. Synthesis, Characterization, Crystal Structure and DFT Studies of 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1-(2,2,2-Trifluoroethyl)-1H-Pyrazole. Molecular Crystals and Liquid Crystals, 2022, 745(1): 60-67.

18.Tao Liu, Yi Ai, Jie Ding, Bingqing Li, Changguang Zeng, Xiaohan Zhang, Hang Zhong*, Zhixu Zhou*. Synthesis, crystal structure, DFT and anticancer study of dihydroartermisinin-paracetamol hybrids. Journal of Molecular Structure, 2022, 1250, (2): 131758.

19.Yumei Chen, Zhongyuan Wang, Dongmei Chen, Wenjun Ye, Tianhui Liao, Chunshen Zhao, Weike Liao, Zhixu Zhou*. Synthesis, crystal and molecular structure, DFT, vibrational spectroscopic, hirshfeld surfaces analyses and molecular docking of a novel compound N-(3-((1-(5-bromo-2-(pyrrolidin-1-yl)phenyl)-5-oxo-[1,2,4]triazolo[4,3-a] quinazolin-4(5H)-yl)methyl)phenyl)-2-thiomorpholinoacetamide. Journal of Molecular Structure, 2022, 1250:131796.

20.Qingmei Wu, Wenjun Ye, Qian Guo, Tianhui Liao, Di Yang, Chunshen Zhao, WeikeLiao, Huifang Chai,Zhixu Zhou*. Synthesis, crystal and molecular structure, vibrational spectroscopic, DFT and molecular docking of 4-(2-chlorobenzyl)-1-(4-hydroxy-3-((4-hydroxypiperidin-1-yl)methyl-5-methoxyphenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Journal of Molecular Structure, 2022, 1247, 131367.

21.Tianhui Liao, Wenjun Ye, Dongmei Chen, Yumei Qin, Yumei Chen, Weike Liao, Zhixu Zhou*. Synthesis, Crystal Structure and DFT Study of 4-(2-Chlorobenzyl)-1-(furan-2-yl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Journal of Heterocyclic Chemistry, 2022, 59(1): 137-143.

22.Tianhui Liao, Weiyin Hu, Hong Sun, Wenjun Ye, Qian Guo, Zhixu Zhou*. Synthesis, crystal structure, DFT calculations and vibrational properties studies of methyl (tert-butoxycarbonyl)-L-tyrosinate and methyl (2,2,2-trifluoroacetyl)-L-tyrosinate. Journal of Structural Chemistry, 2022, 63(1): 64 - 66.

23.Biao-Dan Tang, Jia-Yan Zhang, Hai-Xiang Ma, Na Wang, Xu An, Guang-Mei Li, Zhixu Zhou*. Synthesis, crystal structure and DFT study of 1-(pyrrolidin-1-ylmethyl)-4-(thiophen-2-ylmethyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Journal of Structural Chemistry, 2022, 63(1): 11 - 13.

24.Liyuan Deng, Hong Sun, Weiyin Hu, Wanpeng Liao, Zhixu Zhou*, Hongyan Pan*. Synthesis, crystal structure, and DFT study of a new derivative of pyrido[2,3-d]pyrimidine. Russian Journal of General Chemistry, 2021, 91: 2489 - 2496.

25.Rongshuang Luo, Zhongyuan Wang, Dali Luo, Yumei Qin, Chunshen Zhao, Di Yang, Tian Lu, Zhixu Zhou*, Zhuyan Huang*. Design, synthesis, and biological evaluation of novel triazoloquinazolinone derivatives as SHP2 protein inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36 (1): 2170 - 2182.

26.Zhixu Zhou, Qing-mei Wu, Zhuyan Huang, Dehou Yu, Hongguang Lu*. Synthesis, crystal structure, DFT, molecular docking and antitumor activity of 4-(2-chlorobenzyl)-1-(5-fluoro-2-hydroxy-3-((4-methylpiperidin-1-yl)methyl) phenyl)-[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one. Research on Chemical Intermediates, 2021, 47: 3609-3627.

27.Dongmei Chen, Yumei Chen, Qingmei Wu, Xiaohan Zhang, Weike Liao, Zhixu Zhou*. Synthesis, crystal structure and vibrational properties of N-(8-(3-(3-(tert-butyl)ureido)phenyl)imidazo[1,2-a]pyridin-6-yl)acetamide. Journal of Molecular Structure, 2021, 1245: 131101.

28.Dongmei Chen, Yumei Chen, Di Yang, Zhaopeng Zheng, Zhixu Zhou*. Synthesis and anti-tumor activity of novel pyridino[2,3-d]pyrimidine urea derivatives. Journal of Heterocyclic Chemistry, 2021, 58: 1628-1636.

29.Zhixu Zhou, Ye Liu, Qian Ren, Dehou Yu, Hongguang Lu*. Synthesis, crystal structure and DFT study of a novel compound N-(4-(2,4-dimorpholinopyrido[2,3-d]pyrimidin-6-yl) phenyl)pyrrolidine-1-carboxamide.Journal of Molecular Structure, 2021, 1235: 130261.

30.Qingmei Wu, Yumei Chen, Dongmei Chen, Zhixu Zhou*. Synthesis, crystal structure and vibrational properties studies of 2-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)benzonitrile and N-(3-bromobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline. Journal of Molecular Structure, 2021, 1229: 129782.

31.Wenjun Ye, Dongmei Chen, Qingmei Wu, Yumei Chen, Dezheng Yang, Tianhui Liao, Zhixu Zhou*. Synthesis, crystal structure and DFT study of tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate. Journal of Structural Chemistry, 2021, 62, 1357–1364.

32.Yumei Chen, Dongmei Chen, Qingmei Wu, Wenjun Ye, Chunshen Zhao, Weike Liao, Zhixu Zhou*. Synthesis, crystal structure and DFT study of a novel (2S,2'S,6R,6'R)-4,4'-(6-bromopyrido[2,3-d]pyrimidine-2,4-diyl)bis(2,6-dimethylmorpholine). Journal of Structural Chemistry, 2021, 62(10): 1606-1615.

33.Minggang Teng^#, Zhixu Zhou^#, Yumei Qin, Yongli Zhao, Chunshen Zhao*, Jianxin Cao*. A water-soluble fluorescence sensor with high specificity for detecting hydrazine in river water detection and A549 cell imaging. Sensors & Actuators: B. Chemical, 2020, 311: 127914.

34.Dan Long, Yumei Qin, Qingmei Wu, Xue Zou, Zhixu Zhou*. Synthesis, crystal structure and DFT study of 4-(3,5-dimethylisoxazol-4-yl)benzene-1,2-diol. Journal of Structural Chemistry, 2019, 60(8): 1339-1344.

35.叶文君，陈玉梅，陈冬梅，郭倩，周志旭*．5-溴-2-（4-甲基哌啶-1-基）嘧啶的晶体结构及密度泛函理论研究．人工晶体学报. 2021,50(11): 2116-2122.

36.吴清梅，张秋艳，黄朋越，周志旭*. 2-二氟甲氧（硫）基吡啶-5-硼酸频哪醇酯类化合物的合成. 化学研究与应用. 2021,33(04): 731-734.

37.陈冬梅，陈玉梅，吴清梅，周志旭*. 3-叔丁基-1-（3-羟基苯基）脲的晶体结构及密度泛函理论研究. 人工晶体学报. 2021,50(03): 523-529.

38.陈玉梅，陈冬梅，杨致松，周志旭*. 2-氟-5-氯-3,4-二溴硝基苯的合成及晶体结构研究. 化学试剂. 2020,42(08): 992-994.

39.龙丹，吴清梅，赵庆平，周志旭*. 1-（1-乙基丙基）-5,6-二甲基-7-硝基-1H-苯并咪唑的合成. 化学试剂. 2019,41(08): 851-854.

参编教材：

1.《制药技术人员从业就业指南》（主编），中国医药科技出版社，2024年.

2.《制药工艺学》（副主编），中国中医药出版社，2023年.

3.《药物合成反应》（参编），人民卫生出版社，2023年.

4.《制药技术人员从业实战案例》（副主编），人民卫生出版社，2023年.

5.《中药制药设备与车间设计》（副主编），中国中医药出版社，2022年.

6.《药物制剂设备》（副主编），中国医药科技出版社，2021 年.

7.《制药原理与设备》（参编），上海科学技术出版社，2019 年.

8.《制药工程设计》（参编），中国中医药出版社，2018年.

授权专利：

1. 周志旭. 一种吡啶并[2,3-d]嘧啶类化合物及其制备方法和用途. 专利号：ZL2020111774872.

2. 周志旭,叶文君, 赵春深. 一种五元杂环并喹唑啉酮类化合物及其制备方法. 专利号：ZL2021110310254.

社会兼职：

1. 《中南药学》青年编委；

2. 《中国药物化学杂志》青年编委；

3. 《沈阳药科大学学报》青年编委。